100% Oli e Hloekileng ea Tlhaho ea Eucommiae Foliuml Oli ea Bohlokoa Bakeng sa Tlhokomelo ea Letlalo

tlhaloso e khuts'oane:

Eucommia ulmoides(EU) (eo hangata e bitsoang "Du Zhong" ka puo ea Sechaena) ke ea lelapa la Eucommiaceae, leloko la sefate se senyenyane se hlahang Chaena Bohareng [1]. Semela sena se lengoa haholo Chaena ka tekanyo e kholo ka lebaka la bohlokoa ba sona ho tsa bongaka. Metsoako e ka bang 112 e qheletsoe ka thoko ho EU e kenyelletsang lignans, iridoids, phenolics, steroids, le metsoako e meng. Motsoako oa litlama tse tlatselletsang tsa semela sena (joalo ka tee e monate) o bonts'itse lisebelisoa tse ling tsa bongaka. Lekhasi la EU le na le ts'ebetso e phahameng e amanang le cortex, lipalesa le litholoana [2,3]. Ho tlalehoa hore makhasi a EU a matlafatsa masapo le mesifa ea 'mele [4], ka hona ho lebisa bophelo bo bolelele le ho khothalletsa batho ho ba le bana [5]. Ho tlalehoa hore foromo ea tee e monate e entsoeng ka lekhasi la EU e fokotsa ho nona le ho matlafatsa metabolism ea matla. Metsoako ea Flavonoid (joalo ka rutin, chlorogenic acid, ferulic acid le caffeic acid) e bonts'a ts'ebetso ea li-antioxidants makhasi a EU.6].

Leha ho bile le lingoliloeng tse lekaneng mabapi le thepa ea phytochemical ea EU, ho bile le lithuto tse fokolang tse mabapi le thepa ea pharmacological ea metsoako e fapaneng e ntšitsoeng makhapetleng, peo, stems le makhasi a EU. Pampiri ena ea tlhahlobo e tla hlakisa lintlha tse qaqileng mabapi le metsoako e fapaneng e ntšitsoeng likarolong tse fapaneng (makhapetla, lipeo, kutu le lekhasi) tsa EU le ts'ebeliso e lebelletsoeng ea metsoako ena meahong e khothalletsang bophelo bo botle e nang le bopaki ba mahlale, kahoo e fana ka boitsebiso bo ka sebelisoang. bakeng sa ts'ebeliso ea EU.

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Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lignans le tse tsoang ho tsona ke likarolo tsa bohlokoa tsa EU [7]. Ho fihlela joale, li-lignan tse 28 (tse kang bisepoxylignans, monoepoxylignans, neolignans, le sesquilignans) li qheletsoe ka thoko ho makhapetla, makhasi le peo ea EU. Iridoid glycoside, sehlopha sa metabolites ea bobeli, ke karolo ea bobeli ea mantlha ea EU. Li-Iridoids li fumanoa limela tse tsejoang e le glycosides. Li-iridoids tse mashome a mabeli a metso e mene li khethiloe 'me li khethiloe ho tsoa ho EU (Lethathamo la 1). Metsoako ena e ka thoko e kenyelletsa geniposidic acid, aucubin, le asperuloside tseo ho tlalehiloeng hore li na le thepa e ngata ea pharmacological [8-10]. Metsoako e 'meli e mecha ea li-iridoids, Eucommides-A le -C, e sa tsoa aroloa. Metsoako ena e 'meli ea tlhaho e nkuoa e le li-conjugates tsa iridoid le amino acid. Leha ho le joalo, mochine o tsamaisang mosebetsi oa bona ha o fumanehe [11].

2.2. Metsoako ea Phenolic

Ho tlalehoa hore metsoako ea phenolic e nkiloeng lijong e na le phello e ntle bophelong ba batho.12,13]. Hoo e ka bang metsoako ea phenolic e ka bang 29 e khethiloe 'me ea khetholloa ho tsoa ho EU [14]. Kakaretso ea metsoako ea phenolic (ka li-gallic acid tse lekanang le li-extracts tsohle) li ile tsa hlahlojoa ho sebelisoa Folin-Ciocalteu phenol reagent. Litlamorao tsa phapang ea linako tsa selemo ho likahare tsa metsoako e meng le li-antioxidants li tlalehiloe. Selemong sona seo, litaba tse phahameng tsa phenolics le flavonoids li ile tsa sibolloa makhasi a EU ka Phato le Mots'eanong, ka ho latellana. Rutin, quercetin, geniposidic acid, le aucubin li bile teng ka bongata ka May kapa June.15]. Ho feta moo, ts'ebetso e phahameng ea ts'ebetso ea 1,1-diphenyl-2-picrylhydrazyl (DPPH) e matla ea ho senya le bokhoni ba tšepe ea chelating e fumanoe makhasi a EU a kotuloa ka August. Keketseho ea litaba tsa li-antioxidants tsa lijo le eona e tlalehiloe ka Mots'eanong ha e bapisoa le linako tse ling tsa selemo [15]. Lekhasi la EU le fumanoe e le mohloli o ruileng oa li-amino acid, livithamine, liminerale le li-flavonoids tse kang quercetin, rutin le geniposidic acid.11,16]. Kakaretso ea li-flavonoids tse 7 li arotsoe ho tsonaEucommialimela [17]. Rutin le quercetin ke flavonoids ea bohlokoa ka ho fetisisa.18]. Li-Flavonoids ke metsoako ea bohlokoa e tloaelehileng ka tlhaho 'me e nkoa e le metabolites ea bobeli' me e sebetsa e le manģosa a lik'hemik'hale, li-physiological regulators le cell cycle inhibitors.

2.3. Steroids le Terpenoids

Li-steroid tse tšeletseng le li-terpenoid tse hlano li ntšitsoe 'me li arotsoe ho tsoa ho EU. Tsena li kenyelletsaβ-sitosterol, daucosterol, ulmoprenol, betalin, betulic acid, ursolic acid, eucommidiol, rehmaglutin C, le 1,4α,5,7α-tetrahydro-7-hydroxymethyl-cyclopenta[c]pyran-4-carboxylic methyl ester e neng e arohane ka ho khetheha le makhapetla a EU.19]. Loliolide e boetse e arotsoe makhasi [20].

2.4. Li-polysaccharides

Li-polysaccharides tse tsoang EU bakeng sa matsatsi a 15 ho 300-600 mg / kg li ile tsa tlalehoa hore li na le liphello tse sireletsang liphio joalokaha li hlokometsoe ke maemo a malonaldehyde le glutathione ka mor'a hore ho be le li-renal perfusions.21]. Tlhahlobo ea histological e boetse e bonts'a bopaki ba thepa ea antioxidative. Lits'oants'o tse tsoang makhapetla a EU a sebelisang 70% ethanol le tsona li bonts'itse litlamorao tsa tšireletso khahlanong le cadmium ho 125-500 mg / kg.22]. Tlhahlobo ea histological e boetse e bontša hore EU hammoho lePanax pseudoginsengka boima ba 25% le 50%, ka ho latellana, ka libeke tse tšeletseng ka tekanyo ea tekanyo ea 35.7-41.6 mg / kg e hlahisitse liphello tse sireletsang tse khanyang ka tekanyo ea glomerular filtration [8]. Li-polysaccharides tse peli tse ncha li arotsoe ho EU, e leng eucomman A le B [23].

2.5. Metsoako e meng le Lik'hemik'hale

Li-amino acid, li-microelements, livithamine le mafura a mafura le tsona li qheletsoe ka thoko ho EU.17,21-23]. Letsatsi le al. e boetse e sibollotse metsoako e mecha e kang n-octacosanoic acid, le tetracosanoic-2,3-dihydroxypropylester e tsoang EU [24].

Sebopeho sa mafura a mafura a oli e ntšitsoeng ho peo ea EU se bontšitse likhahla tse fapaneng tsa mafura a polyunsaturated a kang linoleic acid, linolenic acid (56.51% ea kakaretso ea mafura a mafura, TFAs), le linolelaidic acid (12.66% ea TFAs). Ho sa le joalo, asiti e ka sehloohong ea mafura a monounsaturated e arohaneng le peo e fumanoe e le isoleic acid (15.80% ea TFAs). Li-acid tse ngata tse mafura tse arohaneng li kenyelletsa palmitic acid le stearic acid tse emelang 9.82% le 2.59% ea TFAs, ka ho latellana.