OEM Custom Package Natural Macrocephalae Rhizoma oli

tlhaloso e khuts'oane:

Joaloka moemeli ea sebetsang hantle oa chemotherapeutic, 5-fluorouracil (5-FU) e sebelisoa haholo bakeng sa phekolo ea lihlahala tse kotsi ka har'a pampiri ea mala, hlooho, molala, sefuba le ovary. Mme 5-FU ke moriana oa pele oa mofetše oa mala ka tleliniking. Mokhoa oa ts'ebetso oa 5-FU ke ho thibela phetoho ea uracil nucleic acid ho thymine nucleic acid ka har'a lisele tsa tumor, ebe e ama synthesis le tokiso ea DNA le RNA ho fihlela phello ea eona ea cytotoxic (Afzal et al., 2009; Ducreux et al. al., 2015; Longley et al., 2003). Leha ho le joalo, 5-FU e boetse e hlahisa letšollo le bakoang ke chemotherapy (CID), e 'ngoe ea liketso tse mpe tse atileng haholo tse hlokofatsang bakuli ba bangata (Filho et al., 2016). Ketsahalo ea letšollo ho bakuli ba tšoaroang ka 5-FU e ne e fihla ho 50% -80%, e ileng ea ama ka botebo tsoelo-pele le katleho ea chemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). Ka lebaka leo, ho bohlokoa haholo ho fumana kalafo e sebetsang bakeng sa CID e susumelitsoeng ke 5-FU.

Hajoale, ho kenella ho sa sebeliseng lithethefatsi le ho kenella ka lithethefatsi ho kentsoe kantle ho kalafo ea bongaka ea CID. Mehato e sa sebeliseng lithethefatsi e kenyelletsa lijo tse loketseng, le ho tlatselletsa ka letsoai, tsoekere le limatlafatsi tse ling. Lithethefatsi tse kang loperamide le octreotide li atisa ho sebelisoa kalafo ea anti-letšollo ea CID (Benson et al., 2004). Ntle le moo, li-ethnomedicines li boetse li amoheloa ho phekola CID ka kalafo ea tsona e ikhethang linaheng tse fapaneng. Meriana ea setso ea Sechaena (TCM) ke ethnomedicine e tloaelehileng e 'nileng ea sebelisoa ka lilemo tse fetang 2000 linaheng tsa Asia Bochabela ho kenyeletsa Chaena, Japane le Korea (Qi et al., 2010). TCM e lumela hore litlhare tsa chemotherapeutic li ka baka tšebeliso ea Qi, khaello ea spleen, ho hloka botsitso ka mpeng le mongobo oa endophytic, e leng se bakang ho se sebetse hantle ha mala. Ka khopolo ea TCM, leano la phekolo ea CID le lokela ho itšetleha haholo ka ho tlatsetsa Qi le ho matlafatsa spleen (Wang et al., 1994).

Metso e omisitsoeng eaAtractylodes macrocephalaKoidz. (AM) lePanax ginsengCA Mey. (PG) ke meriana e tloaelehileng ea litlama ho TCM e nang le liphello tse tšoanang tsa ho tlatsetsa Qi le ho matlafatsa spleen (Li et al., 2014). AM le PG hangata li sebelisoa e le litlama tse peli (mofuta o bonolo ka ho fetisisa oa ho lumellana le litlama tsa Chaena) ka liphello tsa ho tlatsetsa Qi le ho matlafatsa spleen ho phekola letšollo. Mohlala, AM le PG li ngotsoe ka mokhoa oa khale oa ho thibela letšollo joalo ka Shen Ling Bai Zhu San, Si Jun Zi Tang ho tsoa.Taiping Huimin Heji Ju Fang(Leloko la lipina, Chaena) le Bu Zhong Yi Qi Tang ho tlohaPi Wei Lun(Leloko la Yuan, Chaena) (Setšoantšo sa 1). Lithuto tse 'maloa tse fetileng li tlalehile hore liforomo tsena tse tharo li na le bokhoni ba ho fokotsa CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Ntle le moo, thuto ea rona e fetileng e bonts'itse hore Shenzhu Capsule e nang le AM ​​le PG feela e na le litlamorao tse ka bang teng kalafong ea letšollo, colitis (xiexie syndrome), le mafu a mang a mala (Feng et al., 2018). Leha ho le joalo, ha ho boithuto bo buileng ka phello le mokhoa oa AM le PG ho phekola CID, ebang ke ka kopanelo kapa e le mong.

Hona joale gut microbiota e nkoa e le sesosa se ka sehloohong sa ho utloisisa mokhoa oa phekolo oa TCM (Feng et al., 2019). Boithuto ba sejoale-joale bo bonts'a hore gut microbiota e bapala karolo ea bohlokoa ho boloka mala a homeostasis. Healthy gut microbiota e thusa ho sireletsa mala a mala, metabolism, homeostasis ea 'mele le karabelo, le khatello ea likokoana-hloko (Thursby le Juge, 2017; Pickard et al., 2017). Disordered gut microbiota e senya ts'ebetso ea 'mele le ea' mele oa motho ka kotloloho kapa ka tsela e sa tobang, e baka karabelo ea lehlakore joalo ka letšollo (Patel et al., 2016; Zhao le Shen, 2010). Lipatlisiso li bontšitse hore 5-FU e fetotse sebopeho sa gut microbiota ka litoeba tsa lets'ollo (Li et al., 2017). Ka hona, litlamorao tsa AM le PM ho letšollo le bakoang ke 5-FU li ka 'na tsa kopanngoa ke gut microbiota. Leha ho le joalo, hore na AM le PG feela 'me li kopane li ka thibela letšollo le bakoang ke 5-FU ka ho fetola gut microbiota ha e e-so tsejoe.

Bakeng sa ho etsa lipatlisiso ka litlamorao tse khahlanong le letšollo le mochini o ka tlase oa AM le PG, re sebelisitse 5-FU ho etsisa mohlala oa letšollo ho litoeba. Mona, re tsepamisitse maikutlo ho liphello tse ka bang teng tsa tsamaiso e le 'ngoe le e kopanetsoeng (AP) eaAtractylodes macrocephalaoli ea bohlokoa (AMO) lePanax ginsengkakaretso ea saponins (PGS), likarolo tse sebetsang ka ho latellana tse nkiloeng ho AM le PG, ka letšollo, lefu la mala le sebopeho sa likokoana-hloko ka mor'a 5-FU chemotherapy.