Theko e ngata ka kakaretso 100% Pure Forsythiae Fructus oil Relax Aromatherapy Eucalyptus globulus

tlhaloso e khuts'oane:

Forsythia e hlolla(Thunb.) Vahl. (Lelapa la Oleaceae) ke sehlahla se khabisitsoeng, seo litholoana tsa sona li sebelisoang e le TCM e tsebahalang "Forsythiae Fructus" (FF) (连翘ka Sechaena). Litšobotsi tsa TCM tsa FF li akaretsoa e le tatso e babang, e nang le serame se batang le matšoafo, pelo kapa intestinum meridian distributions (Pharmacopoeia Commission of PRC, 2015), litšobotsi tseo li tšoana le sebopeho sa TCM e khahlanong le ho ruruha, ho latela Chen. le Zhang (2014). Ka litlama tsa Shennong, FF e ne e sebelisetsoa ho phekola pyrexia, ho ruruha, gonorrhea, carbuncle le erysipelas (Cho et al., 2011). Mefuta e 'meli ea FF e teng, tholoana e tala e butsoitseng e ncha e bitsoang "Qingqiao" le e mosehla e butsoitseng ka ho feletseng e bitsoang "Laoqiao". Ka bobeli li sebetsa e le mehloli ea molao ea FF, leha ho le joalo, Qingqiao e sebelisoa khafetsa ho litaelo tsa TCM (Jia et al., 2015). Libaka tse kholo tsa tlhahiso ea FF ke Hebei, Shaanxi, Shanxi, Shandong, Anhui, Henan, Hubei, Jiangsu (e lengoang) le Liprofinse tsa Sichuan (Boto ea Bahlophisi ea Flora ea Chaena, 1978).

Khatisong ea 2015 ea Chinese Pharmacopoeia, ho thathamisitsoe litokisetso tsa meriana tsa Sechaena tse 114 tse nang le FF, tse kang Shuanghuanglian oral solution, letlapa la Yinqiao Jiedu, matlapa a Niuhuang Shangqing, joalo-joalo (Khomishene ea Pharmacopoeia ea PRC, 2015). Lipatlisiso tsa morao-rao li senola anti-inflammatory ea eona (Kim et al., 2003), antioxidant (CC Chen et al., 1999), antibacterial (Han et al., 2012), anti-cancer (Hu et al., 2007), anti -virus (Ko et al., 2005), anti-allergy (Hao et al., 2010), neuroprotective (S. Zhang et al., 2015) liphello,etc.Le hoja litholoana feela li sebelisoa e le TCM, lithuto tse ling li tlalehile liphello tsa phytochemistry le pharmacological ea makhasi (Ge et al., 2015, Zhang et al., 2015), lipalesa (Takizawa et al., 1981) le peo (Zhang et al. ., 2002) eaF. suspensa. Ka hona, hona joale re fana ka kakaretso e hlophisitsoeng ea tlhahisoleseding e teng eaF. suspensa, ho kenyelletsa le litšebeliso tsa setso, botani, phytochemistry, pharmacology, toxicity, pharmacokinetics le taolo ea boleng. Hape, ho tšohloa litsela tse ka bang teng nakong e tlang tsa lipatlisiso.

Likaroloana tsa karolo

Tšebeliso ea setso

Litemaneng tsa khale tsa litlama tsa Sechaena, FF e tlalehiloe e le ea bohlokoa ho phekola rat fistula, scrofula, carbuncle, seso se kotsi, hlahala ea nyooko, mocheso le chefo (litlama tsa Shennong, Bencao Chongyuan, Bencao Zhengyi, Zhenglei Bencao). Ho ea ka li-classics tse ngata tsa khale, setlama sena sa bongaka se sebetsa haholo ho tlosa mocheso oa kanale ea pelo le ho lokolla mongobo - mocheso oa spleen le mala. E boetse e na le thuso bakeng sa kalafo ea stranguria, edema, qi stagnancy le stasis ea mali.

Botany

F. suspensa(Weeping Forsythia) ke sehlahla se khabisang se tsoaletsoeng Chaena, se hōlang ho fihlela bolelele ba limithara tse 3 (setšoantšo sa 1). E na le li-internode tse sekoti tse nang le makala a atileng kapa a sootho a mosehla-sootho kapa a sootho bo sootho ka 'mala. Hangata makhasi a bonolo, empa ka linako tse ling 3-foliolate. Mahlaku a mahlaku a ovate, ovate ka bophara, kapa elliptic-ovate le 2–10 × 1.5–5 cm2 ka boholo ka motheo o chitja ho isa ho cuneate le apex e bohale. Mahlakore ka bobeli a mahlaku a matala, a benya ka bohale kapa a mahoashe

Phytochemistry

Matsatsing ana, metsoako e 237 e fumanoe hoF. suspensa, ho kenyelletsa le 46 lignans (1-46), 31 phenylethanoid glycosides (47-77), 11 flavonoids (78-88), 80 terpenoids (89-168), 20 derivatives ea cyclohexylethanol (169-188), alkaloids tse tšeletseng (1918) ), li-steroidal tse 'nè (195-198) le metsoako e meng ea 39 (199-237). Har'a bona, likarolo tse peli (21-22) li ne li arohane le lipalesa tsaF. suspensa, likarolo tse 19 (94–100, 107–111, 115–117, 198, 233–235) li ne li arohane le makhasi aF. suspensa, likarolo tse 'nè

Liphello tse khahlanong le ho ruruha

Mesebetsi e khahlanong le ho ruruha ea FF e tšehetsa liphello tsa eona tsa ho hloekisa mocheso (Guo et al., 2015). Ho ruruha ke karabelo ea 'mele ho ts'oaetso ea tšoaetso, allergic, kapa lik'hemik'hale (Lee et al., 2011). E kenella ho nts'etsopele ea mafu a sa foleng, joalo ka mafu a letlalo, allergy le mofetše,etc.FF ke e 'ngoe ea TCM e nang le matla a matla a ho thibela ho ruruha, e sebelisoa haholo ho ruruha ho sa foleng le ho matla. Mesebetsi e khahlanong le ho ruruha ea FF e behile maemo a mahlano ka holimo ho tse 81 tse lekiloeng tsa TCM (70% ea ethanol

Chefo

Ho fihlela joale, ha ho na tlaleho ea chefo ea FF. Tekanyetso ea letsatsi le letsatsi ea tsamaiso ea FF e khothalletsoa hore e be 6-15 g (Khomishene ea Pharmacopoeia ea PRC, 2015). Litlaleho tse amehang li bontšitse hore ha ho chefo e matla ea metsi kapa ethanol e ntšitsoeng makhasi aF. suspensaka litoeba, esita le ka tekanyo ea letsatsi le letsatsi ea 61.60 g / kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han et al. (2017) e tlalehile hore ha ho chefo e matla ea phillyrin (ho tloha makhasi aF. suspensa)ho litoeba tsa NIH (18.1 g/kg/letsatsi, po, ka matsatsi a 14) kapa che

Pharmacokinetics

Li et al. e hloaile metabolites ea karolo e robong ea phillyrin ka lisampole tsa moroto tsa likhoto mme ea hlahisa mekhoa ea eona ea metabolic ho likhoto. Phillyrin qalong e ne e entsoe ka hydrolyzed ho phillygenin mme ea fetoleloa ho li-metabolite tse ling haholo-holo ka methylation, demethylation, dehydroxylation le mekhoa ea ho bula lesale (Li et al., 2014c). H. Wang et al. (2016) e khethile 34 phase I le phase II metabolites ea phillyrin mme e bontšitse hore hydrolysis, oxidation le sulfation e ne e le tse kholo.

Taolo ea boleng

Ho laola boleng ba FF, Pharmacopoeia ea Chaena e fana ka tlhahiso ea boitsebiso ba morphological, microscopic le TLC ho phaella ho boikemisetso ba HPLC. Mehlala ea FF e tšoanelehang e lokela ho ba le phillyrin e fetang 0.150% (Khomishene ea Pharmacopoeia ea PRC, 2015).

Leha ho le joalo, letšoao le le leng la palo, phillyrin, le bonahala le sa lekana ho hlahloba boleng ba FF. Haufinyane tjena, likarolo tse fapaneng tsa bioactive ho FF li ile tsa hlahlojoa ka mokhoa o ikhethileng oa chromatography, electrophoresis, MS le mekhoa ea NMR, joalo ka.

Qetello le maikutlo a kamoso

Tlhahlobo ea hona joale e akaretsa lintlha tse felletseng mabapi le ts'ebeliso ea setso, botani, phytochemistry, litlamorao tsa meriana, chefo, pharmacokinetics le taolo ea boleng.F. suspensa. Litemaneng tsa khale tsa litlama tsa China le Chinese Pharmacopoeia, FF e sebelisoa haholo bakeng sa ho hloekisa mocheso le ho tlosa chefo. Ho fihlela joale, metsoako e fetang 230 e arotsoe 'me ea khetholloa ho tsoa ho setlama sena. Har'a tsona, lignans le phenylethanoid glycosides li nkoa e le tšobotsi le bioactive

Litlhaloso tsa TCM

Yin: "Yin" ke e 'ngoe ea matla a mabeli a tlatselletsanang a tlhaho, ho latela sebopeho sa khale sa Machaena sa bokahohle. "Yin" e khetholloa e le e liehang, e bonolo, e tenyetsehang, e pharalletseng, e batang, e metsi kapa e khutsitseng, 'me e amahanngoa le metsi, lefatše, khoeli, botšehali le bosiu.

Qi: Ka mantsoe a acupuncture, "qi" ke "matla a bophelo". Ke mohloli oa ho sisinyeha hohle ka har'a 'mele, tšireletso khahlanong le tlhaselo ea' mele, mohloli oa ts'ebetso eohle ea metabolic, e fana ka ts'ebetso ea ho ts'oaroa ha lisele.

Liteboho

Mosebetsi ona o ile oa tšehetsoa ke Beijing Joint Project of Science Research ka thuto ea morao-rao ea thuto ea morao-rao - lipatlisiso tsa theknoloji ea Key le ts'ebeliso ea tlhahlobo ea polokeho ea lisebelisoa tse chefo tsa meriana ea Chaena tse thehiloeng ho sebopeho sa lik'hemik'hale le litšobotsi tsa zebrafish.

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Bongata ba Odara:100 Likotoana / Likotoana

Matla a Phepelo:10000 Pejana / Likotoana ka Khoeli

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Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Ethnopharmacological relevance

Forsythiae Fructus (e bitsoang Lianqiao ka Sechaena), tholoana eaForsythia e hlolla(Thunb.) Vahl, e sebelisoa e le moriana o tloaelehileng oa setso Chaena, Japane le Korea. Ka tloaelo e sebelisoa ho phekola pyrexia, ho ruruha,gonorrhea,carbuncleleerysipelas. Ho ipapisitsoe le nako ea kotulo e fapaneng, Forsythiae Fructus e ka aroloa ka mefuta e 'meli, e leng Qingqiao le Laoqiao. Litholoana tse tala tse qalang ho butsoa li bokelloa e le Qingqiao, ha litholoana tse mosehla tse butsoitseng ka ho feletseng li bokelloa e le Laoqiao. Ka bobeli li sebelisoa ts'ebelisong ea bongaka. Tlhahlobo ena e ikemiselitse ho fana ka kakaretso e hlophisitsoeng eaF. suspensa(Forsythia e hlolla(Thunb.) Vahl) le ho senola kamano pakeng tsa ts'ebeliso ea setso lemesebetsi ea merianae le ho fana ka ts'usumetso bakeng sa lipatlisiso tsa nako e tlang.

Lisebelisoa le mekhoa

Lintlha tsohle tse tsamaellanang mabapi leF. suspensae ile ea batlisisoa ke Scifinder 'me ea fumanoa ho tsoa litsing tsa boitsebiso tsa saense ho kenyeletsa Springer, Science Direct, Wiley, Pubmed le China Knowledge Resource Integrated (CNKI). Lipuisano le libuka tsa sebaka seo le tsona li ile tsa phenyekolloa.

Liphetho

Ho ea ka lingoliloeng tsa khale tsa China tsa litlama le Chinese Pharmacopoeia, Forsythiae Fructus e bonts'a haholo litlamorao tsa ho tlosa mocheso le ho tlosa chefo ka har'a naha.TCMditaelo tsa ngaka. Lipatlisisong tsa morao-rao, metsoako e fetang 230 e ile ea aroloa 'me ea khetholloa ho tlohaF. suspensa. 211 Ho bona ho ne ho kgethehile ditholwana.Lignansle phenylethanoidli-glycosidesli nkuoa e le likarolo tse sebetsang le tse sebetsang tsa setlama sena, joalo ka forsythiaside, phillyrin,rutinle phillygenin. Ba bonts'a li-anti-inflammatory, antioxidant, antibacterial, antivirus, anti-cancer le anti-allergy effects,etc.Hajoale, ha ho na tlaleho mabapi le chefo ea Forsythiae Fructus, leha ho na le chefo e nyane ea forsythiaside e tlalehiloeng likhatisong tsa lehae. Ha ho bapisoa le Laoqiao, Qingqiao e na le maemo a holimo a forsythiaside, forsythoside C, cornoside,rutin, phillyrin,asiti ea galliclechlorogenic acidle maemo a tlase a rengyol,β-glucose le S-suspensasidemethyl ether.

Qetello

Liketso tsa ho hloekisa mocheso tsa Forsythiae Fructus li thehiloe holim'a thepa ea anti-inflammatory le antioxidant ea lignans le phenylethanoid.li-glycosides. Litlamorao tsa detoxifying li hlahisoa ke ts'ebetso ea antibacterial, antiviral le anti-mofets'e ea Forsythiae Fructus. 'Me meriana ea setso ea Machaena (TCM) ea Forsythiae Fructus (tatso e babang, tlhaho e batang hanyenyane le matšoafo a meridian) a tšehetsa liphello tsa eona tse matla tse khahlanong le ho ruruha. Ho phaella moo, e tsotehang e khahlanong le ho ruruha lematla a antioxidantea Forsythiae Fructus e kenya letsoho ho e thibelang mofetše leneuroprotectivemesebetsi. Karolo e phahameng ea lignans le phenylethanoid glycosides Qingqiao ho feta Laoqiao e ka hlalosa bokhoni bo betere ba antioxidant ba Qingqiao le ts'ebeliso ea khafetsa ea QingqiaoTCMditaelo tsa ngaka. Bakeng sa lipatlisiso tse tlang, ho fetaka vivoliteko le lithuto tsa bongaka li khothaletsoa ho hlakisa haholoanyane kamano lipakeng tsa ts'ebeliso ea setso le lits'ebetso tsa sejoale-joale. Mabapi le Qingqiao le Laoqiao, li sa ntse li lokela ho khetholloa ka mekhoa eohle ea ho laola boleng, 'me metsoako ea lik'hemik'hale le liphello tsa kliniki pakeng tsa tsona li lokela ho bapisoa.